@article{Kumar_Chauhan_Rajan_Paul_2021, title={Metastatic Angiosarcoma: A Rare Malignancy}, volume={2}, url={https://ej-clinicmed.org/index.php/clinicmed/article/view/127}, DOI={10.24018/clinicmed.2021.2.5.127}, abstractNote={<p class="Text"><span lang="EN-US">Angiosarcoma is an infrequent vascular malignancy with grave prognosis due to distant metastasis at initial presentation. The predominant metastatic sites of angiosarcoma are lung; and it is particularly important and should be approached with multimodality treatment because pulmonary metastasis of angiosarcoma frequently induces severe complications. Here, we reported a case of angiosarcoma in an old Indian male presented with cough and hemoptysis. 18-FDG PET-CT scan revealed multiple organ involvement by tumor, and excisional biopsy from lung and pleural nodule revealed malignant tumor composed of spindle shaped epithelioid cell. Strong positivity for D2-40, CD 31 & CD 34 favoured the diagnosis of angiosarcoma. Patient was planned for intravenous chemotherapy with paclitaxel along with zoledronic acid. After 3-cycles of chemotherapy, re-evaluation with PET-CT revealed good response. In view of stable disease, it was planned to continue the same regimen for three more cycles. However, after receiving two more cycles of chemotherapy, patient’s condition deteriorated rapidly and died within a month. The present case showed, paclitaxel has a good impact on metastatic angiosarcoma to diminish lung nodules. However, more effective treatment regimen should be explored to effectively treat metastatic angiosarcoma and increase survival.</span></p>}, number={5}, journal={European Journal of Clinical Medicine}, author={Kumar, Ramashish and Chauhan, Ashok K. and Rajan, Blessy K. and Paul, Diptajit}, year={2021}, month={Oct.}, pages={7–9} }